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Practical guides on pre-submission methodological and statistical review for clinical researchers.

What a pre-submission statistical review covers
The questions and checks a statistical review runs before submission, the two moments it is worth doing, and what it costs.
Published July 2026
Why manuscripts get rejected for statistics
The common methodological and statistical reasons reviewers reject papers, and how to catch them first.
Published June 2026
Why editors desk-reject before peer review
The screen a manuscript clears before a reviewer ever sees it — and the avoidable reasons it fails.
Published July 2026
How journals catch statistical errors
The screens editors and reviewers run — from eyeballed arithmetic to automated consistency checkers.
Published July 2026
The GRIM test: catching impossible means
A one-line arithmetic check that flags reported means a given sample size cannot produce.
Published July 2026
When a p-value doesn't match its test statistic
A reported p that doesn't follow from its test statistic and degrees of freedom — and what it signals.
Published July 2026
Post-hoc power is meaningless — what to do instead
Why observed power adds nothing to a finished study, and the precision statements reviewers are actually asking for.
Published July 2026
The STROBE checklist, item by item
A pre-submission walkthrough of the 22-item reporting guideline for observational studies.
Published July 2026
The CONSORT checklist, item by item
A pre-submission walkthrough of the reporting guideline for randomized controlled trials.
Published July 2026
The TRIPOD checklist, item by item
A pre-submission walkthrough of the reporting guideline for clinical prediction models.
Published July 2026
The PRISMA checklist, item by item
A pre-submission walkthrough of the reporting guideline for systematic reviews and meta-analyses.
Published July 2026
Responding to Reviewer 2's statistics comments
How to answer the hard statistical critiques in a revision — point by point, without spin.
Published July 2026
A reviewer asked for a statistician — what now?
What the comment usually means, the four real options, and how to answer the letter honestly in each case.
Published July 2026
Statistical review options before you submit
Ways to get a statistical read before submission, and where an automated pre-submission review fits.
Published June 2026
Case study: an imprecise null read as a finding
Reading a moderate-severity report on a multi-hospital colectomy cohort — where the gap is framing, not error.
Published July 2026
Case study: reverse causation in a risk model
A serious finding in a pulmonary-embolism prediction model — a strong model whose central claim outruns the evidence.
Published July 2026
Case study: catching what the record already knew
Running the engine on a landmark trial retracted for randomization irregularities — and sizing it correctly.
Published July 2026