Critical manuscript appraisal for editors, reviewers, and readers.
Critical Review is in early access. It is designed to help editors, reviewers, and readers assess study design, analysis, and conclusions. Join early access for updates about this separate workflow.
§01 Choose the review mode
The same PDF can raise different questions depending on whether you are handling a submission, drafting a peer-review critique, or reading a published paper for clinical use. Critical Review will keep those outputs separate and will open as a distinct report workflow rather than a hidden variant of the standard review.
The full workflow will use this for journal-fit and evidentiary-standard appraisal. Analytics receives only the selected mode.
- Risk-based disposition estimate framed as editorial triage, not a final decision.
- Journal-fit assessment against audience, article type, scope, novelty expectations, clinical relevance, and methodological bar.
- Prioritized must-fix list split by validity, statistics, reporting, interpretation, journal fit, and minor editorial issues.
- Explicit reanalysis flag and a concise reviewer-facing summary.
§02 What the report is designed to surface
§03 The structured checklist
Each mode will examine manuscript methods and present the proposed output for its reader's role.
One question runs through every area: fit between the manuscript text, reported methods, available results, and the claim being made. When the PDF lacks the needed detail, the report says not assessable rather than guessing.
- Study design clarity
- Population and eligibility
- Exposure/intervention definition
- Outcome definition
- Comparator/control definition
- Confounding control
- Missing data
- Model specification
- Clustering/hierarchical structure
- Multiplicity
- Power/sample size
- Effect estimates and precision
- Tables/figures consistency
- Abstract accuracy
- Discussion overclaiming
- Ethics/IRB/data source transparency
- References and literature positioning
§04 Outputs stay role-specific
- Validity-threatening issues
- Statistical and reanalysis issues
- Reporting and transparency issues
- Interpretation and overclaiming issues
- Journal-fit or framing issues
- Minor editorial issues
- No reanalysis apparent
- Targeted reanalysis recommended
- Major reanalysis likely required
- Analysis not assessable from PDF alone
- Practice-changing
- Practice-informing
- Hypothesis-generating only
- No clear clinical action