Free tools

Planning calculations you can verify

Free, deterministic study-planning tools for clinical researchers. No account, no upload — they run in your browser, and every answer is shown with the rule or formula behind it, so you (or your statistician) can check the arithmetic.

Minimum detectable effect
You can enroll only so many patients. Given that n, what is the smallest true difference your study could reliably detect — and is it clinically meaningful?
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Which statistical test?
Outcome type, group structure, pairing, adjustment — answered as structured choices — mapped to an estimand-first primary analysis with its assumptions and fallback.
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These are the same deterministic engines inside RigorMD’s $10 study design plan — pure rule tables and closed-form formulas, no AI in the loop. The free tools show you one honest number or one recommended test. The full plan turns your study description into the whole scaffold: the analysis plan, the variables and data you need to collect, a clearly stated hypothesis with the power to answer it, and a draft IRB statistical-methods page.

A planning scaffold, not a certification. These tools flag what a design can and cannot detect and suggest an analysis to discuss — they do not certify a study, and they are not a substitute for a qualified biostatistician. Have any sample-size justification or analysis plan reviewed before you enroll patients or submit to an IRB.